Italian Penicillin Soup: Comfort in Every Spoonful

Last Updated on October 9, 2025 by Chef Josie

When the weather turns cold or you’re craving something nourishing and restorative, Italian Penicillin Soup is exactly what you need. Inspired by the Italian tradition of simple, healing broths, this dish combines homemade chicken broth, delicate pasta, fresh herbs, and a touch of Parmesan to create a comforting bowl that’s as good for the soul as it is for the body.

The name might sound playful, but its roots are genuine. Italians have long believed in the healing power of a homemade chicken soup simmered slowly with love and good ingredients. It’s the Italian answer to the classic “Jewish Penicillin”, a soothing, aromatic broth that revives you from the inside out.

This stovetop version is straightforward, deeply flavorful, and fits perfectly among your favorite Soup Recipes for cold weather or quick weeknight dinners.

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Why You’ll Love This Recipe

• Nourishing and restorative: Light yet full of flavor, perfect for when you need a comforting meal.
• Quick and easy: Ready in under 40 minutes, ideal for those who love Easy Soup Recipes.
• Wholesome ingredients: Made with real, simple foods that are naturally good for you.
• Perfect for all seasons: A staple among Winter Soup Recipes and Fall Soups and Stews.
• Customizable: Adjust the vegetables or pasta to suit your preferences.

Ingredient Breakdown

2 tablespoons olive oil – Adds richness and helps sauté the aromatics.
1 small onion, finely chopped – The base flavor for your broth.
2 carrots, diced – Sweetness and texture.
2 celery stalks, diced – Classic depth for chicken soup.
3 cloves garlic, minced – Essential for that warm Italian flavor.
8 cups chicken broth (homemade or low-sodium) – The backbone of the soup.
1 cup small pasta (stelline, orzo, or ditalini) – Traditional Italian pasta shapes for soup.
2 cups shredded cooked chicken – A great use for leftovers or rotisserie chicken.
½ teaspoon dried oregano – Earthy balance.
Salt and black pepper to taste – Adjust before serving.
2 tablespoons chopped fresh parsley – Fresh and fragrant finish.
¼ cup grated Parmesan cheese – Adds savory depth and richness.

Optional additions:

• Add spinach or kale for extra nutrients.
• Use turkey instead of chicken after holiday meals.
• A squeeze of lemon brightens the flavor.

Step-by-Step Instructions

1. Sauté the aromatics:
   Heat olive oil in a large pot over medium heat. Add onion, carrots, and celery. Cook for 5–6 minutes, stirring occasionally, until the vegetables soften. Add garlic and cook for another 30 seconds.
2. Add broth and seasonings:
   Pour in the chicken broth. Stir in oregano, salt, and pepper. Bring to a boil.
3. Add pasta and cook:
   Add your pasta directly into the simmering broth. Cook for 8–10 minutes or until the pasta is tender but not mushy.
4. Add chicken and finish:
   Stir in shredded chicken. Lower the heat and simmer gently for another 5 minutes to allow flavors to blend.
5. Garnish and serve:
   Ladle soup into bowls. Sprinkle with chopped parsley and grated Parmesan cheese before serving.

Notes & Top Tips

• Don’t overcook the pasta: It continues to soften as the soup sits. Cook it al dente.
• Use good broth: The flavor of this soup depends heavily on the quality of your stock.
• Make it vegetarian: Use vegetable broth and add cannellini beans instead of chicken.
• Add greens: Spinach or kale can be stirred in at the end for extra nutrients.
• Meal prep friendly: Keeps well for several days and reheats beautifully.

Serving Suggestions & Variations

• Serve with: Crusty Italian bread, focaccia, or a simple side salad.
• Add spice: Sprinkle with red pepper flakes for a light kick.
• Creamy version: Stir in a splash of cream or a dollop of ricotta before serving.
• Classic twist: Add a squeeze of lemon for brightness or a drizzle of olive oil for richness.

Storage & Reheating Tips

• Refrigerate: Store in airtight containers for up to 4 days.
• Freeze: Cool completely and freeze up to 3 months (omit pasta if freezing, then add fresh when reheating).
• Reheat: Warm gently on the stove, adding broth as needed to thin.

Why You’ll Make It Again and Again

This Italian Penicillin Soup is more than just a meal; it’s comfort, tradition, and nourishment in one bowl. It’s simple to make, deeply satisfying, and a timeless addition to your favorite Soup Recipes collection.

If you make it, share your version and leave a comment, your family might just call it their new favorite cure-all.

FAQs

Can I use leftover chicken?
Yes, this recipe is perfect for using rotisserie or leftover roasted chicken.

Can I make this gluten-free?
Use gluten-free pasta or rice for a celiac-friendly option.

Is it healthy?
Absolutely. Made with lean protein, broth, and vegetables, it’s one of the best Healthy Soup Recipes you can make.

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